Isabella is a girl from Italy who tends to make all sorts of impractical inventions as seen in the episode Inventor Mentor. She is voiced by Nika Futterman.
Isabella is a young girl, when she speaks she has an Italian accent. She has short brown hair, she wears a pink collared shirt with a green skirt, she also wears pink shows with white high socks.
Isabella is an aspiring inventor, she tries her best to be creative but it ends up with her inventing useless impractical things, she's smart enough to come up with some inventions that can be used for everyday household necessities. Uncle Grandpa brought Leonardo da Vinci to the future to be her inventor mentor to give her advice and to teach her that necessity is the mother of invention.
- Isabella has the same voice actor as Luna Loud from "The Loud House".